反应详情

A solution of 997 mg (5.28 mmol) of (4-azidopentyl)-benzene and 672 mg (8 mmol) of cyanoacetamide in 3 ml of DMSO is admixed with a solution, of a temperature of 50° C., of 127 mg (5.5 mmol) of sodium in 3 ml of ethanol. The reaction mixture is stirred at room temperature for 15 h and then poured into 25 ml of ice-water. The pH is adjusted to pH 2 using 1N HCl and the precipitated solid is filtered off with suction, washed with water and dried under reduced pressure. This gives 1.14 g (79%) of a slightly yellow solid.

1. filtrationthe precipitated solid is filtered off with suction
2. washwashed with water
3. customdried under reduced pressure