2-(Dimethylamino)ethanol → HCID 18416274, compound

Temperature

50 °C

To a suspension of sodium hydride (NaH) 60% dispersion in mineral oil (4.5 g, 111 mmol, 1.1 eq.) in anhydrous DMF (200 mL) was added 2-dimethylaminoethanol (11.5 mL, 111 mmol. 1.1 eq.). The reaction mixture was heated to 50° C. for 30 min. Then, 6-chloronicotinonitrile (14.8 g, 101 mmol, 1 eq.) in THF (100 mL) was added dropwise and the mixture was stirred overnight at 50° C. The solvents were removed under reduced pressure, the resulting residue was dissolved in water and acidified with conc. HCl (hydrochloric acid) to pH 1. The solution was washed with CH2Cl2 (2×200 mL), the aqueous layer was basified with conc. NaOH (sodium hydroxide) to pH about 10 and extracted with diethyl ether. The organic phase was washed with brine, dried over Na2SO4, and filtered. Removal of the solvent in vacuo gave the title compound as an off-white solid (19.32 g, 99%) (m.p.:58° C.).

1. customThe solvents were removed under reduced pressure
2. dissolutionthe resulting residue was dissolved in water
3. washThe solution was washed with CH2Cl2 (2×200 mL)
4. extractionextracted with diethyl ether
5. washThe organic phase was washed with brine
6. dry with materialdried over Na2SO4
7. filtrationfiltered
8. customRemoval of the solvent in vacuo

ORD record

ord-67e1291a17464d37aa6cdd496dbadada

Source dataset

uspto-grants-2002_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06462047B1