反应详情

420 mg of NaH (60% in oil, 10.3 mmol) were added in portions to 1.0 g of 3-cyanoindazole (7.0 mmol) and 1.7 ml of benzyl bromide (14.0 mmol) in 6 ml of THF, and the mixture was stirred at room temperature for 15 hours. The reaction was quenched with 2 drops of water, the mixture was concentrated and the residue was chromatographed (SiO2; petroleum ether:ethyl acetate 3:1). 1.3 g of a solid were obtained.

1. customThe reaction was quenched with 2 drops of water
2. concentrationthe mixture was concentrated
3. customthe residue was chromatographed (SiO2; petroleum ether:ethyl acetate 3:1)