Acetic Acid → HCID 53812005, compound

HRID 990980Notes

Reaction equation

HRID 990980 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12](=[O:14])[CH3:13])=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.[CH:15](=O)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C(O)(=O)C.N1CCCCC1>CO>[CH:15](=[C:3]1[CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[C:7]([NH:11][C:12](=[O:14])[CH3:13])[CH:6]=2)[C:2]1=[O:1])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 240BenzaldehydeHCID 8082PiperidineHCID 312894N-(1-Oxo-2,3-dihydro-1H-inden-5-yl)acetamide

Product 1

HCID 53812005HCID 53812005, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of N-(1-oxoindan-5-yl)acetamide (10.0 g, obtained from the Maybridge Chemical Co. Ltd), benzaldehyde (6.73 g), glacial acetic acid (1.06 g) and piperidine (10.8 g) was heated to 90° C. under nitrogen. Methanol (200 ml) was added and the mixture was cooled and then filtered to give N-(2-benzylidene-1-oxo-indan-5-yl)acetamide (13.47 g).

Workup

  1. customobtained from the Maybridge Chemical Co
  2. temperaturethe mixture was cooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-a7e9ee60c9f1473f8addba167aa7d804
Source dataset
uspto-grants-2002_10
Patent number
US06462036B1

Reaction notes

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