反应详情

Sodium metal (5.24 g, 0.23 g atm) was reacted with 25 mL of absolute ethanol. To this solution was added dropwise, with stirring, diethyl malonate (36.0 mL, 0.24 mol). The solution was heated to reflux and 2-bromopentane (29.0 mL, 0.23 mol) was added dropwise. After refluxing overnight, the reaction was cooled and the ethanol removed on a rotovap. The product was washed with water, dried with MgSO4 and fractionally distilled to give 35.7 g of the desired product.

1. additionTo this solution was added dropwise
2. temperatureThe solution was heated
3. temperatureto reflux
4. temperatureAfter refluxing overnight
5. temperaturethe reaction was cooled
6. customthe ethanol removed on a rotovap
7. washThe product was washed with water
8. dry with materialdried with MgSO4
9. distillationfractionally distilled