Dimethylformamide → 1'-[1-(4-Bromophenyl)cyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one

HRID 99748Notes

Reaction equation

HRID 99748 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([C:11](=[O:12])[OH:13])[CH2:9][CH2:10]2)[cH:6][cH:7]1.[CH3:14][N:15]([CH3:16])[CH:17]=[O:18].[CH3:33][C:34]1([CH3:35])[CH:36]2[CH2:37][CH2:38][C:39]1([CH2:40][S:41]([OH:42])(=[O:43])=[O:44])[C:45](=[O:46])[CH2:47]2.[CH:75]([N:76]([CH2:77][CH3:78])[CH:79]([CH3:80])[CH3:81])([CH3:82])[CH3:83].[NH:19]1[CH2:20][C:21]2([O:22][C:23](=[O:30])[c:24]3[c:25]2[cH:26][cH:27][cH:28][cH:29]3)[CH2:31][CH2:32]1.[P-:48]([F:49])([F:50])([F:51])([F:52])([F:53])[F:54].[n:55]1([O:56][P+:57]([N:58]([CH3:59])[CH3:60])([N:61]([CH3:62])[CH3:63])[N:64]([CH3:65])[CH3:66])[c:67]2[cH:68][cH:69][cH:70][cH:71][c:72]2[n:73][n:74]1>>[Br:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([C:11](=[O:13])[N:19]3[CH2:20][C:21]4([O:22][C:23](=[O:30])[c:24]5[c:25]4[cH:26][cH:27][cH:28][cH:29]5)[CH2:31][CH2:32]3)[CH2:9][CH2:10]2)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 18462Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)-HCID 81531DiisopropylethylamineHCID 124335Benzotriazol-1-yloxy-tris(dimethylamino)phosphoniumHCID 162279661-(4-Bromophenyl)cyclopropane-1-carboxylic acidHCID 215068143H-Spiro[2-benzofuran-1,3'-pyrrolidin]-3-one

Product 1

HCID 666616101'-[1-(4-Bromophenyl)cyclopropanecarbonyl]spiro[2-benzofuran-3,3'-pyrrolidine]-1-one

Sources & evidence

ORD record
ord-d979b7d96f7843d89849e496e68317e8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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