Cyanoacetamide → Piperidine

HRID 1075831

Reaktionsgleichung

Reaktionsgleichung von HRID 1075831
[Na].C([N:5]1CC[N:8]([C:11]2[CH:21]=[CH:20][C:14]([C:15](CC=O)=O)=CC=2)CC1)CC.C[O-].[Na+].C(N1CC[N:31]([C:34]2C=[CH:38][C:37]([C:40](=[O:42])C)=[CH:36][CH:35]=2)CC1)CC.C(OCC)=O.C(CC(N)=O)#N>O.C(O)(=O)C.O1CCCC1>[NH:8]1[CH2:11][CH2:21][CH2:20][CH2:14][CH2:15]1.[O:42]=[C:40]1[NH:31][CH:34]=[CH:35][CH:36]=[C:37]1[C:38]#[N:5]

Komponenten

11

Edukt 6

HCID 7898CyanoacetamideHCID 8025Ethyl formateHCID 5360545SodiumHCID 10942334Sodium MethoxideHCID 21404502p-(4-Propyl-1-piperazinyl)acetophenoneHCID 54256791p-(4-Propyl-1-piperazinyl)benzoylacetaldehyde

Produkt 2

HCID 8082PiperidineHCID 5775433-Cyano-2-pyridone

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel2×HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

From a solution of the sodium salt of p-(4-propyl-1-piperazinyl)benzoylacetaldehyde in 150 ml. of water (prepared from 5.7 g. of sodium methoxide in 500 ml. of tetrahydrofuran, and a solution of 24.6 g. of p-(4-propyl-1-piperazinyl)acetophenone and 8.0 ml. of ethyl formate in 100 ml. of tetrahydrofuran), 8.4 g of 2-cyanoacetamide and a solution consisting of 0.95 ml. of acetic acid, 4.0 ml. of water and 0.9 ml. of piperidine, there is obtained 6-[p-propyl-1-piperazinyl)phenyl]-1,2-dihydro-2-oxonicotinonitrile; m.p. 288°-290° (dec.).

Quellen und Nachweise

ORD-Eintrag
ord-c374f6d440074cc4b6a9415448a92f57
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03954734

Verknüpfte Notizen

Wird geladen…