Water → 6H-thiazolo[5,4-e]indazol-2-amine

HRID 1360834

Reaktionsgleichung

Reaktionsgleichung von HRID 1360834
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.[S-:11][C:12]#[N:13].[Na+].BrBr.O>C(O)(=O)C>[S:11]1[C:3]2[C:4]3[CH:5]=[N:6][NH:7][C:8]=3[CH:9]=[CH:10][C:2]=2[N:1]=[C:12]1[NH2:13]

Komponenten

6

Edukt 4

HCID 962WaterHCID 24408BromineHCID 880121H-Indazol-5-amineHCID 516871Sodium thiocyanate

Produkt 1

HCID 450776746H-thiazolo[5,4-e]indazol-2-amineAusbeute 108,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

2.0 g (15 mmol) of 5-aminoindazole and 4.9 g (60.5 mmol) of sodium thiocyanate were suspended in 10 ml of acetic acid, and 2.4 g (15 mmol) of bromine was added dropwise to the suspension under ice-cooling. The reaction mixture was allowed to warm to room temperature, and it was stirred overnight. The reaction mixture was poured into water, and the resulting crystals were collected by filtration to give 3.1 g of 6H-pyrazolo[4′,3′:3,4]benzo[1,2-d]thiazol-2-ylamine.

Aufarbeitung

  1. temperaturecooling
  2. filtrationthe resulting crystals were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-a08db6a131d245279357b2eff5f3a1bc
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07879887B2

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