Acetic Acid → HCID 13013041, Verbindung

HRID 1403373Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1403373
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([O:11][CH2:12]C(=O)C(=O)C)[CH:3]=1.[CH3:18][C:19]([O-:21])=O.[Na+].[CH3:23]C(O)=O>CC(OC(C)=O)=O.O>[C:19]([O:8][C:6]1[C:5]2[CH:9]=[CH:10][C:2]([CH3:23])=[CH:3][C:4]=2[O:11][CH:12]=1)(=[O:21])[CH3:18]

Komponenten

6

Edukt 3

HCID 176Acetic AcidHCID 517045Sodium AcetateHCID 70665220HCID 70665220, Verbindung

Produkt 1

HCID 13013041HCID 13013041, VerbindungAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 7918Acetic AnhydrideLösungsmittel

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

To a solution of 4-chloro-2-(2,3-dioxobutoxy)benzoic acid (5 g, 19.48 mmol) in HOAc (80 mL) and Ac2O (100 mL) was added NaOAc (4.2 g, 51.22 mmol). After stirring for 3 h at 150° C., the resulting mixture was dissolved in water (1000 mL), extracted with ethyl acetate (3×200 mL), dried over anhydrous magnesium sulfate and concentrated in vacuo to give 6-methyl-1-benzofuran-3-yl acetate as off-white oil (3.8 g, 85%).

Aufarbeitung

  1. extractionextracted with ethyl acetate (3×200 mL)
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-98536ad5ec0f437fb76c37e11d577311
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08912188B2

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