Acetic Acid → 9H-fluorene-2-carbonitrile

HRID 1678372Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1678372
[CH:1]1[C:13]2[CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][C:2]=1[CH:14]=O.C([O-])(=O)C.[Na+].[Cl-].O[NH3+:23].C(O)(=O)C>O>[C:14]([C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[CH2:12][C:13]=2[CH:1]=1)#[N:23]

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 21645Hydroxylamine HClHCID 34804Fluorene-2-carboxaldehydeHCID 517045Sodium Acetate

Produkt 1

HCID 173029H-fluorene-2-carbonitrileAusbeute 63,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

25 g of 2-fluorenecarboaldehyde, 11.6 g of sodium acetate, 9.7 g of hydroxy ammonium chloride and 150 ml of acetic acid were stirred at 130 for 18 hours. The reaction mixture was allowed to room temperature, poured into 200 ml of water and the precipitate was collected by filtration. The crude product was purified by column chromatography, giving 15.57 g (63%) of 2-cyanofluorene.

Aufarbeitung

  1. customwas allowed to room temperature
  2. filtrationthe precipitate was collected by filtration
  3. customThe crude product was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-c38194389ac749a1a244c711695c52a3
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08008507B2

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