4-Bromoanisole → 2-(4-Methoxyphenyl)benzonitrile

To a solution of 4-bromoanisole (18.7 g, 0.1 mol) in anhydrous tetrahydrofuran (200 mL) at -78° C. was added a solution of n-butyl lithium (2.5M, 50 mL) in hexane. After stirring for 0.5 hours, a solution of the zinc chloride (1M, 100 mL) in ether was added. After the mixture was stirred for 1 hour at -78° C., tetrakis (triphenylphosphine) palladium (0.85 g, 0.73 mmol) and 2-bromobenzonitrile (18.2 g, 0.1 mol) were added. The reaction mixture was stirred at room temperature overnight, and then was concentrated in vacuo. The residue was partitioned between ethyl acetate (100 mL) and 1N hydrochloric acid (100 mL). The organic solution was washed with brine and dried over magnesium sulfate. Concentration in vacuo gave crude 4-(2-cyanophenyl)anisole, which was directly used for next reaction. The compound can be triturated with ether to obtain a pure solid product.

1. stirringAfter the mixture was stirred for 1 hour at -78° C.
2. stirringThe reaction mixture was stirred at room temperature overnight
3. concentrationwas concentrated in vacuo
4. customThe residue was partitioned between ethyl acetate (100 mL) and 1N hydrochloric acid (100 mL)
5. washThe organic solution was washed with brine
6. dry with materialdried over magnesium sulfate
7. concentrationConcentration in vacuo

ORD-Eintrag

ord-7842e73193204e33a44698038c9ab303

Quelldatensatz

uspto-grants-1995_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05380719