Acetic Acid → 1-methyl-3-({[2-phenyl-2-(tetrahydro-2H-pyran-4-yl)ethyl]amino}methyl)quinolin-2(1H)-one

HRID 1943020

Reaktionsgleichung

Reaktionsgleichung von HRID 1943020
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([CH:12]=O)[C:3]1=[O:14].C([O-])(=O)C.[Na+].[Cl-].[C:21]1([CH:27]([CH:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[CH2:28][NH3+:29])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(O)(=O)C.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCCl>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([CH2:12][NH:29][CH2:28][CH:27]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:30]2[CH2:31][CH2:32][O:33][CH2:34][CH2:35]2)[C:3]1=[O:14]

Komponenten

7

Edukt 5

HCID 176Acetic AcidHCID 517045Sodium AcetateHCID 49146281-Methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 673936932-phenyl-2-(tetrahydro-2H-pyran-4-yl)ethanaminium chloride

Produkt 1

HCID 584159371-methyl-3-({[2-phenyl-2-(tetrahydro-2H-pyran-4-yl)ethyl]amino}methyl)quinolin-2(1H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel

Versuchsvorschrift

1-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde (35 mg, 0.187 mmol), sodium acetate (19.94 mg, 0.243 mmol), and 2-phenyl-2-(tetrahydro-2H-pyran-4-yl)ethanaminium chloride (45.2 mg, 0.187 mmol) were combined in 1,2 dichloroethane (2 ml). Acetic acid (0.021 ml, 0.374 mmol) and sodium triacetoxyborohydride (119 mg, 0.561 mmol) were added and the reaction stirred for 20 hours. The mixture was partitioned between CH2Cl2 and satd. bicarb and the aqueous portion was extracted 3×CH2Cl2. The organic portion was dried (Na2SO4) and concentrated in vacuo. The resulting material was purified by reversed-phase chromatography (10-60% ACN in water (with 2 ml/l NH4OH) over 20 min at 20 ml/min, 20×100 mm Phenomenex Gemini C18 column). Desired fractions were concentrated in vacuo. 50.5 mg, 73%.

Aufarbeitung

  1. customThe mixture was partitioned between CH2Cl2 and satd
  2. extractionbicarb and the aqueous portion was extracted 3×CH2Cl2
  3. dry with materialThe organic portion was dried (Na2SO4)
  4. concentrationconcentrated in vacuo
  5. customThe resulting material was purified by reversed-phase chromatography (10-60% ACN in water (with 2 ml/l NH4OH) over 20 min at 20 ml/min, 20×100 mm Phenomenex Gemini C18 column)
  6. concentrationDesired fractions were concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-50dcf7ee4d7f482ebf7fc6e8c48bf8e5
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08389720B2

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