Acetic Acid → 2-Cyano-7-methoxybenzofuran-4-carboxylic acid

HRID 2084816Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2084816
[C:1]([C:3]1[O:4][C:5]2[C:6](=[C:8]([CH:14]=[O:15])[CH:9]=[CH:10][C:11]=2[O:12][CH3:13])[CH:7]=1)#[N:2].C(O)(=[O:18])C.S(=O)(=O)(O)N.Cl([O-])=O.[Na+]>O>[C:1]([C:3]1[O:4][C:5]2[C:6](=[C:8]([C:14]([OH:18])=[O:15])[CH:9]=[CH:10][C:11]=2[O:12][CH3:13])[CH:7]=1)#[N:2]

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 5987Sulfamic AcidHCID 227342992-Cyano-7-methoxybenzofuran-4-carbaldehydeHCID 23668197Sodium Chlorite

Produkt 1

HCID 227341122-Cyano-7-methoxybenzofuran-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of Compound IIi (0.2 g) obtained in Reference Example 9, a 80% aqueous solution (2 ml) of acetic acid, sulfamic acid (0.145 g), and a 80% aqueous solution (0.084 g) of sodium chlorite was stirred at room temperature one night. The mixture was diluted with water, and then the precipitated solid was collected by filtration and dried to give Compound IIab (0.259 g, 83%) as white crystals.

Aufarbeitung

  1. customobtained in Reference Example 9
  2. filtrationthe precipitated solid was collected by filtration
  3. customdried
  4. customto give Compound IIab (0.259 g, 83%) as white crystals

Quellen und Nachweise

ORD-Eintrag
ord-2e13650f45cf4fb1875be7e20ba527b4
Quelldatensatz
uspto-grants-2004_04
Patentnummer
US06716987B1

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