Sodium Carbonate → 4-Amino-2,3-dichlorophenyl thiocyanate

HRID 2120365Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2120365
[Cl:1][C:2]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[S-:10][C:11]#[N:12].[Na+].BrBr.[Br-].[Na+].C(=O)([O-])[O-].[Na+].[Na+]>CO.O>[Cl:1][C:2]1[C:8]([Cl:9])=[C:7]([S:10][C:11]#[N:12])[CH:6]=[CH:5][C:3]=1[NH2:4]

Komponenten

8

Edukt 5

HCID 10340Sodium CarbonateHCID 118442,3-DichloroanilineHCID 24408BromineHCID 253881Sodium BromideHCID 516871Sodium thiocyanate

Produkt 1

HCID 146019304-Amino-2,3-dichlorophenyl thiocyanateAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittel2×HCID 962WaterLösungsmittel

Versuchsvorschrift

To a cold (0-5° C.) solution of 2,3-dichloroaniline (2 g) and sodium thiocyanate (3 g) in MeOH (30 ml), was added a solution of bromine (2 g) in MeOH (10 ml) saturated with sodium bromide. The solution was left to stir for 1 hour. The reaction mixture was poured into water (200 ml) and neutralised with sodium carbonate to pH 8. The solid was collected by filtration and dried to yield the title compound as a white solid (2.38 g) 88%. NMR: 6.35 (s, 2H), 6.81 (d, 1H), 7.55 (d, 1H); m/z (EI+): 218.

Aufarbeitung

  1. waitThe solution was left
  2. filtrationThe solid was collected by filtration
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-600422e8e40042edadd21a0ca46711ee
Quelldatensatz
uspto-grants-2004_02
Patentnummer
US06689909B1

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