Cesium fluoride → 4-Acetylamino-3-chloro-6-(4-chloro-2-fluoro-5-methoxyphenyl)pyridine-2-carboxylic acid methyl ester

HRID 2249388

Reaktionsgleichung

Reaktionsgleichung von HRID 2249388
[CH3:1][O:2][C:3]([C:5]1[C:10]([Cl:11])=[C:9]([NH:12][C:13](=[O:15])[CH3:14])[CH:8]=[C:7](Cl)[N:6]=1)=[O:4].[Cl:17][C:18]1[C:23]([O:24][CH3:25])=[CH:22][C:21](B2OCCCO2)=[C:20]([F:32])[CH:19]=1.[F-].[Cs+].C1(P(C2C=CC=CC=2)CCCCP(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(#N)C.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.O>[CH3:1][O:2][C:3]([C:5]1[C:10]([Cl:11])=[C:9]([NH:12][C:13](=[O:15])[CH3:14])[CH:8]=[C:7]([C:21]2[CH:22]=[C:23]([O:24][CH3:25])[C:18]([Cl:17])=[CH:19][C:20]=2[F:32])[N:6]=1)=[O:4]

Komponenten

8

Edukt 4

HCID 25953Cesium fluorideHCID 821241,4-Bis(diphenylphosphino)butaneHCID 22677481Methyl 4-acetamido-3,6-dichloropyridine-2-carboxylateHCID 669547012-(4-Chloro-2-fluoro-5-methoxyphenyl)-[1,3,2]-dioxaborinane

Produkt 1

HCID 686005934-Acetylamino-3-chloro-6-(4-chloro-2-fluoro-5-methoxyphenyl)pyridine-2-carboxylic acid methyl esterAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 167845palladium(II) acetateKatalysatorHCID 962WaterLösungsmittelHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of 4-acetylamino-3,6-dichloropyridine carboxylic acid methyl ester (4.3 g, 0.016 mol), 2-(4-chloro-2-fluoro-5-methoxyphenyl)-[1,3,2]-dioxaborinane (4.5 g, 0.018 mol), cesium fluoride (3.5 g, 0.025 mol), and 1,4-bis(diphenylphosphino)butane (0.360 g, 0.0016 mol) in acetonitrile (100 mL) was degassed with nitrogen for 15 minutes before palladium acetate (0.180 g, 0.0016 mol) was added and the solution heated under reflux for 18 hours. Water (150 mL) was added and the resulting solid collected and dried to give 4-acetylamino-3-chloro-6-(4-chloro-2-fluoro-5-methoxyphenyl)pyridine-2-carboxylic acid methyl ester (4.5 g, 0.012 mol): mp 180-182° C.

Aufarbeitung

  1. additionwas added
  2. temperaturethe solution heated
  3. temperatureunder reflux for 18 hours
  4. customthe resulting solid collected
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-3afd6bd59fae4532bce4e1eba2f0e7dc
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07314849B2

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