Hydroxyamine hydrochloride → N-[(1S)-1,3,3-Trimethylbicyclo[2.2.1]heptan-2-ylidene]hydroxylamine

HRID 582917Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 582917
Cl.[NH2:2][OH:3].C([O-])(=O)C.[Na+].[CH3:9][C@@:10]12[C:16](=O)[C:15]([CH3:19])([CH3:18])[C@@H:13]([CH2:14]1)[CH2:12][CH2:11]2>O.CO>[CH3:9][C@@:10]12[CH2:14][CH:13]([CH2:12][CH2:11]1)[C:15]([CH3:19])([CH3:18])[C:16]2=[N:2][OH:3]

Komponenten

6

Edukt 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 1201521d-Fenchone

Produkt 1

HCID 71362104N-[(1S)-1,3,3-Trimethylbicyclo[2.2.1]heptan-2-ylidene]hydroxylamineAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 23 g of hydroxylamine hydrochloride and 41 g of sodium acetate in 200 ml of water is added at RT to a solution of 38.1 g of (1S)-(+)-fenchone in 120 ml of MeOH and the mixture is then refluxed for 48 hours. After cooling to RT, the precipitate formed is filtered off, washed with water and dried under vacuum to give 41 g of the expected product.

Aufarbeitung

  1. temperaturethe mixture is then refluxed for 48 hours
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. washwashed with water
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-d68ee45e103d4ea48d0b855e928f69fb
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05925768

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