Acetic Acid → 2-Chloro-6-ethylaminobenzothiazole

HRID 604229Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 604229
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([Cl:9])[S:8][C:4]=2[CH:3]=1.[CH:12](=O)[CH3:13].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].C(O)(=O)C>ClC(Cl)C.O>[Cl:9][C:7]1[S:8][C:4]2[CH:3]=[C:2]([NH:1][CH2:12][CH3:13])[CH:11]=[CH:10][C:5]=2[N:6]=1

Komponenten

7

Edukt 4

HCID 176Acetic AcidHCID 177AcetaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 109212032-Chloro-1,3-benzothiazol-6-amine

Produkt 1

HCID 670401072-Chloro-6-ethylaminobenzothiazole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 63651,1-DichloroethaneLösungsmittel

Versuchsvorschrift

To a solution of (29) (0.2 mmol, 36.8 mg) in 2 ml dichloroethane was added 0.2 mmol acetaldehyde, followed by 63.6 mg sodium triacetoxyborohydride, and 12 μl acetic acid. After 2 h, the solution was poured into water and extracted with ethyl acetate. The combined extracts were washed with water, dried over sodium sulfate, and the solvent removed by rotary evaporation.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe combined extracts were washed with water
  3. dry with materialdried over sodium sulfate
  4. customthe solvent removed by rotary evaporation

Quellen und Nachweise

ORD-Eintrag
ord-bb0506d62e22418a86d84a5049b532a7
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07910087B2

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