2,6-Dibromopyridine → 6-Bromo-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine

HRID 727

Reaktionsgleichung

Reaktionsgleichung von HRID 727
Brc1cccc(Br)n1.NC1CCOCC1>C1COCCO1.CC(=O)O.CC(=O)O.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.O=C([O-])[O-].[Cs+].[Cs+].[Pd]>Brc1cccc(NC2CCOCC2)n1

Komponenten

7

Edukt 2

HCID 122742,6-DibromopyridineHCID 4192234-Aminotetrahydropyran

Produkt 1

HCID 639627976-Bromo-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amineAusbeute 0 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 10796Cesium carbonateReagenzHCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)KatalysatorHCID 4144353Palladium (II) acetateKatalysatorHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

to 2,6-dibromopyridine (100 mg, 0.42 mmol), 4-Aminotetrahydropyran (42.7 mg, 0.42 mmol) in dioxane (3 mL) while bubbling N2 was added Xantphos (24.43 mg, 0.04 mmol), CS2CO3 (316 mg, 0.97 mmol) and palladium(II) acetate (9.48 mg, 0.04 mmol). This was heated in a microwave at 130 oC for 30 mins. A small peak corresponding to product was obseved. Discontinued

Quellen und Nachweise

ORD-Eintrag
ord-13cef69f8e724020954e5476c0d66794
Quelldatensatz
750 AstraZeneca ELN dataset
Originallink
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