Hydrochloric Acid → 1-[4-(Methylthio)phenyl]-1-propanone

HRID 846234Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 846234
[C:1]1([S:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9](Cl)(=[O:12])[CH2:10][CH3:11].[Al+3].[Cl-].[Cl-].[Cl-].Cl>ClC(Cl)C.O>[CH3:8][S:7][C:1]1[CH:6]=[CH:5][C:4]([C:9](=[O:12])[CH2:10][CH3:11])=[CH:3][CH:2]=1

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 7520ThioanisoleHCID 62324Propionyl chlorideHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 8211711-[4-(Methylthio)phenyl]-1-propanone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 63651,1-DichloroethaneLösungsmittel

Versuchsvorschrift

To a mixture of thioanisole (5.0 g) and propionyl chloride (3.9 ml) at 0° C. in dichloroethane (80 ml) was added AlCl3 (6.4 g) in portions. The mixture was stirred 12 hours at ambient temperature, poured into water (200 ml) and conc. HCl (2 ml), then extracted with CH2Cl2. The extract was reduced to dryness to provide the title compound mp 60°-61° C. after purification by chromatography on silica gel.

Aufarbeitung

  1. extractionextracted with CH2Cl2

Quellen und Nachweise

ORD-Eintrag
ord-78d5b8b098dc4f279cc9c0013bc77c03
Quelldatensatz
uspto-grants-1992_08
Patentnummer
US05135940

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