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1,2-Dichloroethane → 3-t-Butoxycarbonylamino-2-(RS)-[1-(4-cyanobenzyl)-1H-imidazol-5-yl]acetylamino-propionic acid methyl ester

HRID 1292670
Notes
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Reaction equation

HRID 1292670 reaction equation
[C:1]([C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[C:12]([CH2:13][C:14]([OH:16])=O)=[CH:11][N:10]=[CH:9]2)=[CH:5][CH:4]=1)#[N:2].[CH3:19][O:20][C:21](=[O:33])[CH:22]([NH2:32])[CH2:23][NH:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26].C1C=C2C(N(O)N=NC2=CC=1)=O.C(N(CC)CC)C.C(Cl)CCl>CN(C=O)C.CCOC(C)=O>[CH3:19][O:20][C:21](=[O:33])[CH:22]([NH:32][C:14](=[O:16])[CH2:13][C:12]1[N:8]([CH2:7][C:6]2[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:18][CH:17]=2)[CH:9]=[N:10][CH:11]=1)[CH2:23][NH:24][C:25]([O:27][C:28]([CH3:29])([CH3:31])[CH3:30])=[O:26]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

8

Reactant 5

HCID 111,2-DichloroethaneHCID 8471TriethylamineHCID 730263-hydroxy-1,2,3-benzotriazin-4(3H)-oneHCID 3442239Methyl 2-amino-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoateHCID 184336301-(4-Cyanobenzyl)imidazole-5-acetic acid

Product 1

HCID 67571752
3-t-Butoxycarbonylamino-2-(RS)-[1-(4-cyanobenzyl)-1H-imidazol-5-yl]acetylamino-propionic acid methyl ester

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of [1-(4-cyanobenzyl)-1H-imidazol-5-yl]acetic acid (607 mg, 1.64 mmol), 3-t-Butoxycarbonylamino-2(RS)-aminopropionic acid methyl ester (352 mg, 1.61 mmol), HOOBT (319 mg, 1.96 mmol), and triethylamine (0.54 ml, 3.87 mmol) in DMF (13 ml) at 0° C., was added EDC (2.67 g, 13.9 mmol). The reaction was stirred at room temperature for 18 hrs, diluted with EtOAc and the organic layer washed with sat. aq NaHCO3, brine, dried (Na2SO4). and the solvent evaporated in vacuo to afford the title compound as a white solid.

Workup

  1. washthe organic layer washed with sat. aq NaHCO3, brine
  2. dry with materialdried (Na2SO4)
  3. customand the solvent evaporated in vacuo

Sources & evidence

ORD record
ord-10bf835f01084d48b6088941cd442011
Source dataset
uspto-grants-1998_05
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05756528

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes