Triethylamine → 6-Tert-butyl-1,3,6-dioxazocan-2-one

HRID 1504567

Reaction equation

HRID 1504567 reaction equation
[C:1]([N:5]([CH2:9][CH2:10][OH:11])[CH2:6][CH2:7][OH:8])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.Cl[C:20](Cl)([O:22]C(=O)OC(Cl)(Cl)Cl)Cl>C1COCC1>[C:1]([N:5]1[CH2:6][CH2:7][O:8][C:20](=[O:22])[O:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62430tert-ButyldiethanolamineHCID 94429Triphosgene

Product 1

HCID 1183802766-Tert-butyl-1,3,6-dioxazocan-2-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The procedure of Example 1 was followed using N-tert-butyl diethanolamine (16.4 g, 83.9 mmol), triethylamine (24.0 mL, 167.8 mmol), dry THF (600 mL) and triphosgene (8.3 g, 28.8 mmol). The filtrate was concentrated yielding a clear oil containing a non-isolable amount of product within a mixture of oligomeric diethanolamines.

Workup

  1. concentrationThe filtrate was concentrated
  2. customyielding a clear oil
  3. additioncontaining a non-isolable amount of product

Sources & evidence

ORD record
ord-bac389f3e44140cb85ac30df467c1168
Source dataset
uspto-grants-2015_12
Patent number
US09215876B2

Linked notes

Loading…