Chloride → 2-Hydroxy-3,3-dimethyl-2,3-dihydrobenzofuran-5-carbonitrile

Reaction equation

[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:13]1)[C:7]([CH3:11])([CH3:12])[CH:8]([OH:10])[O:9]2.[C-:14]#[N:15].[CH3:18][N:19]([CH3:20])[CH:21]=[O:22].[Cl-:16].[ClH:17].[OH2:23]>>[c:2]1([C:14]#[N:15])[cH:3][cH:4][c:5]2[c:6]([cH:13]1)[C:7]([CH3:11])([CH3:12])[CH:8]([OH:10])[O:9]2

Participants

Reactant 6

HCID 312Chloride

HCID 313Hydrochloric Acid

HCID 962Water

HCID 5975Cyanide

HCID 6228Dimethylformamide

HCID 205362245-Bromo-2,3-dihydro-3,3-dimethyl-2-hydroxybenzofuran

Product 1

HCID 205362002-Hydroxy-3,3-dimethyl-2,3-dihydrobenzofuran-5-carbonitrile

Sources & evidence

ORD record: ord-9b24e185a95545aa893bbacfa543b0f2
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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