Lithium Hydroxide → 3-chloro-N2-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-N4-(2-hydroxyethyl)-1H-pyrrole-2,4-dicarboxamide

Temperature

35 °C

To a solution of methyl 3-chloro-4-{[(2-hydroxyethyl)amino]carbonyl}-1H-pyrrole-2-carboxylate (0.048 g, 0.195 mmol) in THF (3 mL) and water (1 mL) was added lithium hydroxide (0.047 g, 1.946 mmol). The reaction mixture was stirred overnight at 35° C. The solvent was evaporated and the resulting solid placed under high vacuum. To the intermediate mixture was added DMF (1 mL), HATU (0.089 g, 0.234 mmol), DIPEA (0.051 ml, 0.292 mmol) and 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile (0.061 g, 0.195 mmol). The solution was stirred for 4 h at RT. Purification was accomplished by HPLC. The desired fractions were neutralized with saturated sodium bicarbonate, extracted with EtOAc (3×5 mL), the organic layers combined, dried over sodium sulfate, filtered and evaporated to afford 3-chloro-N2-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-N4-(2-hydroxyethyl)-1H-pyrrole-2,4-dicarboxamide (0.039 g, 38% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6): δ ppm 12.25 (br. s., 1H) 8.15 (t, 1H) 7.83 (d, 1H) 7.78 (t, 1H) 7.51-7.56 (m, 2H) 7.48 (dt, 2H) 7.37 (t, 1H) 4.57 (d, 2H) 3.46 (t, 2H) 3.25 (q, 2H). MS: m/z 525.0 (M+1).

1. customThe solvent was evaporated
2. stirringThe solution was stirred for 4 h at RT
3. customPurification
4. extractionextracted with EtOAc (3×5 mL)
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. customevaporated

ORD record

ord-89d356e403dc47468b31bd9098daeb40

Source dataset

uspto-grants-2012_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08304419B2