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Phthalimide → 2-(5,7-Difluoroquinolin-6-ylmethyl)isoindoline-1,3-dione

HRID 1892424
Notes
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Reaction equation

HRID 1892424 reaction equation
N(/C(OC(C)C)=O)=N\C(OC(C)C)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[F:34][C:35]1[C:44]([CH2:45]O)=[C:43]([F:47])[CH:42]=[C:41]2[C:36]=1[CH:37]=[CH:38][CH:39]=[N:40]2.[C:48]1(=[O:58])[C:56]2[C:51](=[CH:52][CH:53]=[CH:54][CH:55]=2)[C:50](=[O:57])[NH:49]1>C1COCC1>[F:34][C:35]1[C:44]([CH2:45][N:49]2[C:50](=[O:57])[C:51]3[C:56](=[CH:55][CH:54]=[CH:53][CH:52]=3)[C:48]2=[O:58])=[C:43]([F:47])[CH:42]=[C:41]2[C:36]=1[CH:37]=[CH:38][CH:39]=[N:40]2
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 5363146Diisopropyl azodicarboxylateHCID 69810525(5,7-Difluoroquinolin-6-yl)methanol

Product 1

HCID 698103402-(5,7-Difluoroquinolin-6-ylmethyl)isoindoline-1,3-dioneYield 81%

Reagents, catalysts & solvents 1

HCID 8028
Tetrahydrofuran
Solvent
2×

Conditions

Temperature
40 °C

Procedure

A mixture of (E)-diisopropyl diazene-1,2-dicarboxylate (4.72 g, 23.36 mmol) and triphenylphosphine (6.13 g, 23.36 mmol) in THF (100 mL) was stirred for 15 min, and a solution of (5,7-difluoroquinolin-6-yl)methanol (3.80 g, 19.47 mmol) and isoindoline-1,3-dione (3.15 g, 21.42 mmol) in THF (200 mL) was added dropwise. The reaction mixture was heated at 40° C. for 24 h. After cooling and evaporating, the residue was purified by silica gel with hexane:EtOAc to provide 2-(5,7-difluoroquinolin-6-ylmethyl)isoindoline-1,3-dione (5.10 g, 81%). 1H-NMR (400 MHz, CDCl3) δ ppm 8.93 (m, 1H), 8.39 (m, 1H), 7.85 (m, 2H), 7.72 (m, 2H), 7.59 (d, 1H), 7.43 (m, 1H), 5.15 (s, 2H).

Workup

  1. temperatureAfter cooling
  2. customevaporating
  3. customthe residue was purified by silica gel with hexane

Sources & evidence

ORD record
ord-47d0ef24eff34bab92bd8250a958a934
Source dataset
uspto-grants-2013_08
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08507676B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes