Dimethylformamide → 3-(1-cyanocyclobutyl)-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-4-methylphenyl]benzamide

HRID 190251

Reaction equation

HRID 190251 reaction equation
[C:1](#[N:2])[C:3]1([c:7]2[cH:8][c:9]([C:10](=[O:11])[OH:12])[cH:13][cH:14][cH:15]2)[CH2:4][CH2:5][CH2:6]1.[CH3:22][N:23]([CH3:24])[CH:25]=[O:26].[CH3:51][N:52]1[CH2:53][CH2:54][CH2:55][C:56]1=[O:57].[Cl:16][C:17]([C:18]([Cl:19])=[O:20])=[O:21].[NH2:27][c:28]1[cH:29][cH:30][c:31]([CH3:50])[c:32]([O:33][c:34]2[cH:35][cH:36][c:37]3[n:38]([n:39]2)[cH:40][c:41]([NH:43][C:44](=[O:45])[CH:46]2[CH2:47][CH2:48]2)[n:42]3)[cH:49]1.[O:58]1[CH2:59][CH2:60][CH2:61][CH2:62]1>>[C:1](#[N:2])[C:3]1([c:7]2[cH:8][c:9]([C:10](=[O:12])[NH:27][c:28]3[cH:29][cH:30][c:31]([CH3:50])[c:32]([O:33][c:34]4[cH:35][cH:36][c:37]5[n:38]([n:39]4)[cH:40][c:41]([NH:43][C:44](=[O:45])[CH:46]4[CH2:47][CH2:48]4)[n:42]5)[cH:49]3)[cH:13][cH:14][cH:15]2)[CH2:4][CH2:5][CH2:6]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 13387N-methyl-2-pyrrolidoneHCID 65578Oxalyl chlorideHCID 574410433-(1-Cyanocyclobutyl)benzoic acidHCID 57505483N-[6-(5-amino-2-methylphenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Product 1

HCID 575057013-(1-cyanocyclobutyl)-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-4-methylphenyl]benzamide

Sources & evidence

ORD record
ord-f4b1983dd3434e3cb5cd00456801ac94
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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