4-tert-Butylbenzoic acid → HCID 59293265, compound

A mixture of 4-t-butylbenzoic acid (1.15 g, 6.45 mmol), (R)—N-BOC-3-aminopiperadine (1.00 g, 4.99 mmol), BOP (3.42 g, 7.73 mmol), and N-methylmorpholine (2.5 mL, 22.7 mmol) in DMF (10 mL) was stirred at rt for 2 hr and then heated at 55° C. for 3 hr. It was then diluted with ethyl acetate (150 mL), washed sequentially with water (3×50 mL) and brine (50 mL), and dried over anhydrous MgSO4. Removal of solvent under vacuum provided a crude product of the titled compound, which was used in the next step without further purification.

1. temperatureheated at 55° C. for 3 hr
2. washwashed sequentially with water (3×50 mL) and brine (50 mL)
3. dry with materialdried over anhydrous MgSO4
4. customRemoval of solvent under vacuum

ORD record

ord-65fe8f0ba4ba44e7acad0a021c2efd86

Source dataset

uspto-grants-2012_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08188272B2