Triethylamine → 3-Bromo-5-(3-chlorophenylethynyl)-pyridine

HRID 196081Notes

Reaction equation

HRID 196081 reaction equation
[Br:8][c:9]1[cH:10][n:11][cH:12][c:13]([Br:14])[cH:15]1.[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[CH3:25][CH2:26][O:27][C:28](=[O:29])[CH3:30].[Cl:16][c:17]1[cH:18][c:19]([C:23]#[CH:24])[cH:20][cH:21][cH:22]1.[Cu:31][I:32].[Pd:33]([Cl:34])[Cl:35].[c:36]1([P:37]([c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[cH:50][cH:51][cH:52][cH:53][cH:54]1.[c:55]1([P:56]([c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)[c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)[cH:69][cH:70][cH:71][cH:72][cH:73]1>>[c:9]1([C:24]#[C:23][c:19]2[cH:18][c:17]([Cl:16])[cH:22][cH:21][cH:20]2)[cH:10][n:11][cH:12][c:13]([Br:14])[cH:15]1

Participants

8

Reactant 7

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 693693,5-DibromopyridineHCID 1230861-Chloro-3-ethynylbenzene

Product 1

HCID 670475933-Bromo-5-(3-chlorophenylethynyl)-pyridine

Sources & evidence

ORD record
ord-0aea5281286c42f28d7767ccda7ce738
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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