Triethylsilicon → tert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate
Reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:25][c:24]([c:11]2[CH2:10][CH2:9]1)[c:15]([O:16][CH2:17][c:18]3[cH:23][cH:22][cH:21][cH:20][cH:19]3)[cH:14][c:13](Br)[cH:12]2)=[O:7])([CH3:4])[CH3:3].Clc1cc(Cl)c(O[CH:26]=[O:27])c(Cl)c1.CC[SiH](CC)CC>>[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:25][c:24]([c:11]2[CH2:10][CH2:9]1)[c:15]([O:16][CH2:17][c:18]3[cH:23][cH:22][cH:21][cH:20][cH:19]3)[cH:14][c:13]([CH:26]=[O:27])[cH:12]2)=[O:7])([CH3:4])[CH3:3]Participants
9
Reactant 3
Product 1
Reagents, catalysts & solvents 5
Conditions
- Temperature
- 90 °C
Sources & evidence
- ORD record
- ord-75ba0816f1754674aa25652ed7eae99c
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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