4-Methoxybenzaldehyde → ethyl (E)-3-(4-methoxyphenyl)-2-methylprop-2-enoate
Reaction equation
COc1ccc(C=O)cc1.CCOC(=O)C(C)C(=O)O>C1CCNCC1.CN(C)c1ccncc1.C1CCOC1>CCOC(=O)/C(C)=C/c1ccc(OC)cc1Participants
6
Reactant 2
Product 1
Reagents, catalysts & solvents 3
Conditions
- Temperature
- 25 °C
Workup
- temperatureThe product mixture was cooled to 25 °C.
- filtrationFiltered through a pad of celite · Keep Organic
- wash"The celite was washed with ethyl acetate (3 x 1 mL)."
- concentrationThe filtrate was concentrated under reduced pressure
- additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.
Sources & evidence
- ORD record
- ord-da36f70c3aa54faf8d640c724c947b4b
- Source dataset
- Transfer learning optimization of 26 decarboxylative olefination reactions
Reaction notes
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