[C:1]([C:3]1[CH:39]=[CH:38][C:6]2[N:7](COCC[Si](C)(C)C)[C:8]([CH2:10][C:11]3[C:19]([O:20][CH3:21])=[CH:18][C:17]([CH3:22])=[C:16]4[C:12]=3[CH:13]=[CH:14][N:15]4C(OC(C)(C)C)=O)=[N:9][C:5]=2[CH:4]=1)#[N:2].C(C1C=CC2N=C(CC3C(OC)=CC(C)=C4C=3C=CN4C(OC(C)(C)C)=O)N(COCC[Si](C)(C)C)C=2C=1)#N.[Li+].CC([N-]C(C)C)C.I[CH2:88][CH2:89][CH2:90][C:91]([O:93]C)=[O:92].C(=O)([O-])[O-].[K+].[K+].Cl>C1COCC1.CO.O>[C:1]([C:3]1[CH:39]=[CH:38][C:6]2[NH:7][C:8]([CH:10]([C:11]3[C:19]([O:20][CH3:21])=[CH:18][C:17]([CH3:22])=[C:16]4[C:12]=3[CH:13]=[CH:14][NH:15]4)[CH2:88][CH2:89][CH2:90][C:91]([OH:93])=[O:92])=[N:9][C:5]=2[CH:4]=1)#[N:2]tert-Butyl 4-((5-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)methyl)-5-methoxy-7-methyl-1H-indole-1-carboxylate and tert-butyl 4-((6-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)methyl)-5-methoxy-7-methyl-1H-indole-1-carboxylate (Example 145-A) (510 mg, 0.93 mmol) in THF (10 mL) was stirred at −78° C. and then LDA (2.0M in heptane/THF/ethylbenzene, 0.47 mL, 0.93 mmol) was added and the reaction was stirred for 10 minutes. At this point, methyl 4-iodobutanoate (0.5 mL, 3.7 mmol) was added and the dry ice bath was removed and the reaction was stirred for 2.5 hours at rt. The reaction was diluted with ethyl acetate (100 mL) and poured into saturated aq. solution of sodium chloride. The layers were separated and the organic layer was dried over Na2SO4, concentrated and absorbed onto silica to purify via FCC (0-20% EtOAc:hexanes). The resulting residue was deprotected of the SEM and Boc group using the conditions shown in Example 142-C. The resulting residue (170 mg, 0.408 mmol) was dissolved in MeOH (5 mL) and was added potassium carbonate (180 mg, 1.3 mmol), the reaction was heated at 65° C. overnight. The mixture was then poured into water (50 mL) and the pH was adjusted to −1 with 3 M HCl. The layers were separated and the aqueous layer was extracted with ethyl acetate, dried over Na2SO4, and purified by reverse-phase FCC (0-50%) ACN:water to obtain the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 12.04-12.24 (m, 1H) 11.86-12.03 (m, 1H) 10.88 (s, 1H) 7.93-8.22 (m, 1H) 7.63-7.83 (m, 1H) 7.36-7.52 (m, 1H) 7.12 (t, J=2.81 Hz, 1H) 6.79 (s, 1H) 6.05 (br. s., 1H) 4.87 (dd, J=9.41, 5.62 Hz, 1H) 3.76 (s, 3H) 2.52-2.59 (m, 1H) 2.45 (s, 3H) 2.03-2.30 (m, 3H) 1.48-1.64 (m, 1H) 1.30-1.46 (m, 1H). HRMS calcd. for C23H22N4O3 (M+H)+ 403.1770. found 403.1758.
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