Dimethylformamide → 3-chloro-N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1-methyl-1H-pyrazole-5-carboxamide

HRID 2310852

Reaction equation

HRID 2310852 reaction equation
[CH3:46][N:47]([CH3:48])[C:49](=[O:50])[CH3:51].[CH3:52][N:53]([CH3:54])[CH:55]=[O:56].[Cl:16][C:17]([C:18]([Cl:19])=[O:20])=[O:21].[Cl:1][c:2]1[n:3][n:4]([CH3:10])[c:5]([C:7](=[O:8])[OH:9])[cH:6]1.[NH2:22][c:23]1[cH:24][c:25]([O:26][c:27]2[cH:28][cH:29][c:30]3[n:31]([n:32]2)[cH:33][c:34]([NH:36][C:37](=[O:38])[CH:39]2[CH2:40][CH2:41]2)[n:35]3)[cH:42][cH:43][c:44]1[CH3:45].[O:11]1[CH2:12][CH2:13][CH2:14][CH2:15]1>>[Cl:1][c:2]1[n:3][n:4]([CH3:10])[c:5]([C:7](=[O:8])[NH:22][c:23]2[cH:24][c:25]([O:26][c:27]3[cH:28][cH:29][c:30]4[n:31]([n:32]3)[cH:33][c:34]([NH:36][C:37](=[O:38])[CH:39]3[CH2:40][CH2:41]3)[n:35]4)[cH:42][cH:43][c:44]2[CH3:45])[cH:6]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 31374DimethylacetamideHCID 65578Oxalyl chlorideHCID 189704593-chloro-1-methyl-1H-pyrazole-5-carboxylic acidHCID 57505476N-[6-(3-amino-4-methylphenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Product 1

HCID 575056753-chloro-N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1-methyl-1H-pyrazole-5-carboxamide

Sources & evidence

ORD record
ord-072c49203f4140cb895051951f72165a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Linked notes

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