Acetate → Methyl 4-amino-2-fluorocinnamate

HRID 292447

Reaction equation

HRID 292447 reaction equation
[Br:1][c:2]1[c:3]([F:9])[cH:4][c:5]([NH2:6])[cH:7][cH:8]1.[C:10]([CH:11]=[CH2:12])(=[O:13])[O:14][CH3:15].[C:59]([O-:60])(=[O:61])[CH3:62].[C:64]([O-:65])(=[O:66])[CH3:67].[CH3:16][c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[P:23]([c:24]1[cH:25][cH:26][cH:27][cH:28][c:29]1[CH3:30])[c:31]1[cH:32][cH:33][cH:34][cH:35][c:36]1[CH3:37].[CH3:38][c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1.[CH:50]([N:51]([CH2:52][CH3:53])[CH:54]([CH3:55])[CH3:56])([CH3:57])[CH3:58].[O:45]=[CH:46][N:47]([CH3:48])[CH3:49].[Pd+2:63]>>[c:2]1([CH:12]=[CH:11][C:10](=[O:13])[O:14][CH3:15])[c:3]([F:9])[cH:4][c:5]([NH2:6])[cH:7][cH:8]1

Participants

9

Reactant 8

HCID 175Acetate2×HCID 1140TolueneHCID 6228DimethylformamideHCID 7294Methyl AcrylateHCID 80271Tri-o-tolylphosphineHCID 81531DiisopropylethylamineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 8218484-Bromo-3-fluoroaniline

Product 1

HCID 68485453Methyl 4-amino-2-fluorocinnamate

Sources & evidence

ORD record
ord-ebe6a5d3007f4134b7f16fc77bf0fc3c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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