Piperidine → N-(tert-butoxycarbonyl)piperidine

HRID 4426

Reaction equation

HRID 4426 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].[C:13](=O)([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[O:14]C(Cl)C>C1COCC1>[C:19]([O:18][C:13]([N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:14])([CH3:22])([CH3:21])[CH3:20]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 11430Potassium CarbonateHCID 13557091Tert-butyl 1-chloroethyl carbonate

Product 1

HCID 7010304N-(tert-butoxycarbonyl)piperidine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The procedure is as in Example 7, but with 8.5 g (0.1 mole) of piperidine, 60 ml of THF, 20 ml of saturated aqueous K2CO3 solution and 0.11 mole of α-chloroethyl tert-butyl carbonate.

Sources & evidence

ORD record
ord-c4542c72534e465fbfebfb91c898577a
Source dataset
uspto-grants-1988_02
Patent number
US04725680

Linked notes

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