Hydrazine hydrate (1:1) → (2S,4S)-tert-butyl 4-(4-amino-5-((3,5-dimethoxyphenyl)ethynyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydrazine carbonyl)pyrrolidine-1-carboxylate

Reaction equation

CCN(C(C)C)C(C)C.O.NN.[NH2:13][C:14]1[C:15]2[C:22]([C:23]#[C:24][C:25]3[CH:30]=[C:29]([O:31][CH3:32])[CH:28]=[C:27]([O:33][CH3:34])[CH:26]=3)=[CH:21][N:20]([C@@H:35]3[CH2:39][N:38]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[C@H:37]([C:47](O)=[O:48])[CH2:36]3)[C:16]=2[N:17]=[CH:18][N:19]=1.CN(C(O[N:58]1[N:66]=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>CN(C=O)C.O.C(OCC)(=O)C>[NH2:13][C:14]1[C:15]2[C:22]([C:23]#[C:24][C:25]3[CH:30]=[C:29]([O:31][CH3:32])[CH:28]=[C:27]([O:33][CH3:34])[CH:26]=3)=[CH:21][N:20]([C@@H:35]3[CH2:39][N:38]([C:40]([O:42][C:43]([CH3:44])([CH3:46])[CH3:45])=[O:41])[C@H:37]([C:47]([NH:58][NH2:66])=[O:48])[CH2:36]3)[C:16]=2[N:17]=[CH:18][N:19]=1