Tetrahydrofuran → 4-(1-Cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl-ethynyl)-benzoic acid ethyl ester

Reaction equation

COC(=O)C1C=CC(C#C[C:12]2[CH:13]=[C:14]([CH:26]3[CH2:28]C3)[C:15]3O[C:19]4(CC4)[CH2:18][C:17]([CH3:24])([CH3:23])[C:16]=3[CH:25]=2)=CC=1F.[C:31](O)(=O)[C:32]1[CH:37]=CC=CC=1.[CH2:40]([O:42][C:43](=[O:51])[C:44]1[CH:49]=[CH:48][C:47](I)=[CH:46][CH:45]=1)[CH3:41].C([N:54](CC)CC)C.O1CCCC1>CCCCCC.[Cu]I.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C(OCC)(=O)C>[CH2:40]([O:42][C:43](=[O:51])[C:44]1[CH:49]=[CH:48][C:47]([C:28]#[C:26][C:14]2[CH:15]=[C:16]3[C:25](=[CH:12][CH:13]=2)[N:54]([CH:32]2[CH2:31][CH2:37]2)[CH2:19][CH2:18][C:17]3([CH3:23])[CH3:24])=[CH:46][CH:45]=1)[CH3:41]