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Triethylamine → Phosphoramidic dichloride, bis(2-chloroethyl)-

HRID 649337
Notes
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Reaction equation

HRID 649337 reaction equation
[P:1]([Cl:5])(Cl)([Cl:3])=[O:2].[Cl:6][CH2:7][CH2:8][NH:9][CH2:10][CH2:11][Cl:12].C(N(CC)CC)C.Cl.C(N(CC)CC)C>C1COCC1>[Cl:6][CH2:7][CH2:8][N:9]([CH2:10][CH2:11][Cl:12])[P:1]([Cl:5])([Cl:3])=[O:2]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 9533Bis(2-chloroethyl)amineHCID 11130Triethylamine hydrochlorideHCID 24813Phosphorus oxychloride

Product 1

HCID 96271Phosphoramidic dichloride, bis(2-chloroethyl)-

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Phosphorous oxychloride (0.15 mol) in 100 ml. THF are mixed dropwise at 10° C. with bis-chloroethylamine (0.1 mol) in 100 ml. THF and triethylamine (0.15 mol). After ending of the reaction (TLC verification), triethylamine hydrochloride is filtered off and the filtrate, after the addition of 50 ml. toluene, evaporated. The oily residue is immediately further reacted.

Workup

  1. filtrationis filtered off
  2. additionthe filtrate, after the addition of 50 ml
  3. customtoluene, evaporated
  4. customThe oily residue is immediately further reacted

Sources & evidence

ORD record
ord-c0af85cf54a442ee855b99cb32b2c48a
Source dataset
uspto-grants-1988_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04739095

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes