Dimethylformamide → N-(3-(3-(3-ethyl-3-hydroxypentyl)phenyl)propyl)-2,2,2-trifluoroacetamide

HRID 674508

Reaction equation

HRID 674508 reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH2:8][CH2:9][CH2:10][NH:11][C:12]([C:13]([F:14])([F:15])[F:16])=[O:17])[cH:5][cH:6][cH:7]1.[CH2:18]([CH3:19])[C:20]([C:21]#[CH:22])([CH2:23][CH3:24])[OH:25].[CH3:26][CH2:27][N:28]([CH2:29][CH3:30])[CH2:31][CH3:32].[Cu:79][I:80].[O:33]=[CH:34][N:35]([CH3:36])[CH3:37].[Pd:38]([Cl:39])[Cl:40].[c:41]1([P:42]([c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[cH:55][cH:56][cH:57][cH:58][cH:59]1.[c:60]1([P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[cH:74][cH:75][cH:76][cH:77][cH:78]1>>[c:2]1([CH2:22][CH2:21][C:20]([CH2:18][CH3:19])([CH2:23][CH3:24])[OH:25])[cH:3][c:4]([CH2:8][CH2:9][CH2:10][NH:11][C:12]([C:13]([F:14])([F:15])[F:16])=[O:17])[cH:5][cH:6][cH:7]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 226983-Ethyl-1-pentyn-3-olHCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 57608389N-(3-(3-bromophenyl)propyl)-2,2,2-trifluoroacetamide

Product 1

HCID 86628449N-(3-(3-(3-ethyl-3-hydroxypentyl)phenyl)propyl)-2,2,2-trifluoroacetamide

Sources & evidence

ORD record
ord-c667d312d0a24c038b87ee6b2b207f91
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Linked notes

Loading…