Triethylamine → Methyl 5-sulfamoylthiophene-2-carboxylate

Temperature

100 °C

A mixture of 5-bromothiophene-2-sulfonamide (0.50 g, 2.1 mmol), triethyl amine (1 mL), methanol (1 mL), palladium acetate (0.046 g, 2.1 mmol) and 1,3-bis(diphenylphosphino) propane (0.085 g, 2.1 mmol) (addition in that order) in dimethylformamide (5 mL, anhydrous) is saturated with carbon monoxide gas, at room temperature. This reaction mixture is heated to 100° C. and stirred overnight, under a carbon monoxide atmosphere. 10 mL of brine and 10 mL of ethyl acetate are added to the reaction mixture. The organic phase is separated and the aqueous layer is extracted with 10 mL ethyl acetate. The combined organic layers are dried over sodium sulfate, concentrated in vacuo, and then chromatographed on silica (0–1% methyl alcohol in methylene chloride) to give the title compound, as a yellow solid (0.15 g, 34% yield).

1. customThe organic phase is separated
2. extractionthe aqueous layer is extracted with 10 mL ethyl acetate
3. dry with materialThe combined organic layers are dried over sodium sulfate
4. concentrationconcentrated in vacuo
5. customchromatographed on silica (0–1% methyl alcohol in methylene chloride)

ORD record

ord-7b3ef08a6ec846058fe20b3dbccc2c1d

Source dataset

uspto-grants-2006_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07084170B2