2,6-Dibromopyridine → 6-Bromo-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine
Reaction equation
Brc1cccc(Br)n1.NC1CCOCC1>C1COCCO1.CC(=O)O.CC(=O)O.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.O=C([O-])[O-].[Cs+].[Cs+].[Pd]>Brc1cccc(NC2CCOCC2)n1Participants
7
Reactant 2
Product 1
Reagents, catalysts & solvents 4
Procedure
to 2,6-dibromopyridine (100 mg, 0.42 mmol), 4-Aminotetrahydropyran (42.7 mg, 0.42 mmol) in dioxane (3 mL) while bubbling N2 was added Xantphos (24.43 mg, 0.04 mmol), CS2CO3 (316 mg, 0.97 mmol) and palladium(II) acetate (9.48 mg, 0.04 mmol). This was heated in a microwave at 130 oC for 30 mins. A small peak corresponding to product was obseved. Discontinued
Sources & evidence
- ORD record
- ord-13cef69f8e724020954e5476c0d66794
- Source dataset
- 750 AstraZeneca ELN dataset
- Original link
- View source
Reaction notes
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