Trifluoroacetic acid → 1-benzenesulfonyl-1H-indole-5-carboxylic acid hydroxyamide

NH2OTHP (0.08 g, 0.72 mmol) was added to a solution of 3 (0.18 g, 0.60 mmol), PyBOP (0.33 g, 0.63 mmol), and triethylamine (0.20 ml, 1.43 mmol) in DMF (1.5 mL). The reaction mixture was stirred at room temperature for 2 h before it was quenched with water and extracted with EtOAc (15 mL×3). The combined organic layer was dried over anhydrous MgSO4 and concentrated under reduced pressure. The residue was purified by silica gel chromatography (CH2Cl2:CH3OH=30:1:1% NH3(aq)) to give a white solid, which was treated with TFA (1.70 ml, 22.89 mmol) in the presence of CH3OH (31 mL). The reaction mixture was stirred overnight at room temperature before it was concentrated under reduced pressure to give a white residue. The residue was recrystallized with CH3OH to afford Compound 1 (0.10 g). 1H NMR (500 MHz, CD3OD): δ 6.80 (d, J=3.65 Hz, 1H), 7.49-7.52 (m, 2H), 7.59-7.62 (m, 1H), 7.68 (d, J=8.53 Hz, 1H), 7.75 (d, J=3.72 Hz, 1H), 7.93 (d, J=7.52 Hz, 2H), 7.94-7.97 (m, 1H), 8.04 (d, J=8.53 Hz, 1H); HRMS (EI) for C15H12N2O4S (M+): calcd, 316.0518. found, 316.0518.

1. customwas quenched with water
2. extractionextracted with EtOAc (15 mL×3)
3. dry with materialThe combined organic layer was dried over anhydrous MgSO4
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by silica gel chromatography (CH2Cl2:CH3OH=30:1:1% NH3(aq))
6. customto give a white solid, which
7. stirringThe reaction mixture was stirred overnight at room temperature before it
8. concentrationwas concentrated under reduced pressure
9. customto give a white residue
10. customThe residue was recrystallized with CH3OH

ORD record

ord-f732c9da32ce419e95f414a1422a86c2

Source dataset

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08846748B2