[C:1]1([C:7]2[C:15]3[C:14]([NH2:16])=[N:13][CH:12]=[N:11][C:10]=3[NH:9][C:8]=2[Si:17]([CH2:22][CH3:23])([CH2:20][CH3:21])[CH2:18][CH3:19])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1.[CH2:38]([O:40][CH:41]([O:45][CH2:46][CH3:47])[C:42](O)=[O:43])[CH3:39].[H-].[H-].[H-].[H-].[Li+].[Al+3].C1COCC1>CN(C=O)C.C(OCC)(=O)C.ClCCl>[CH2:38]([O:40][CH:41]([O:45][CH2:46][CH3:47])[C:42]([NH:16][C:14]1[C:15]2[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[C:8]([Si:17]([CH2:20][CH3:21])([CH2:22][CH3:23])[CH2:18][CH3:19])[NH:9][C:10]=2[N:11]=[CH:12][N:13]=1)=[O:43])[CH3:39]To a solution of 5-phenyl-6-(triethylsilyl)-7-H-pyrrolo[2,3-d]pyrimidin-4-amine (Example 5, Step C, 0.45 g, 1.38 mmol), EDC (0.34 g, 1.78 mmol) and HOBT (0.28 g, 2.07 mmol) in DMF (10.0 mL) was added 2,2-diethoxy acetic acid (0.25 g, 14.8 mmol) and the reaction mixture was stirred at rt for 16 h. Dichloromethane (50 mL) was added and the mixture was washed with brine, sat. NaHCO3 solution and brine. The organic layer was dried over Na2SO4, filtered and the filtrate was concentrated. The product was dissolved in 5 mL of THF and slowly added to a 11 mL of a 1 M solution of LiAlH4 in THF (11 mmol) (40 mL) at 0° C. under N2. The temperature of the reaction mixture was allowed to rise to room temperature for 1 hr after addition. The mixture was carefully poured into ice-water (50 mL). Ethyl acetate (50 mL) was added, and the organic layer was separated. The aqueous layer was extracted several times with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4, filtered and the filtrate was concentrated. The residue was purified by chromatography on silica gel (CH2Cl2:MeOH=95:5) to give the title compound. 1H-NMR (400 MHz, DMSO-d6) δ 0.58 (q, 6H, 7.50 Hz), 0.79 (t, 9H, J=8.00 Hz), 1.04 (t, 6H, J=7.00 Hz), 3.40-3.33 (m, 2H), 3.53-3.46 (m, 4H), 4.43 (t, 1H, J=5.50 Hz), 4.84 (t, 1H, J=5.50 Hz), 7.50-7.37 (m, 5H), 8.19 (s, 1H), 11.5 (s, 1H). Mass Spectrum (ESI) m/e=441 (M+1).
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