Acetate → 3-(2-Methylcarbamoyl-pyrimidin 5-yl)acrylic acid benzyl ester

HRID 93864

Reaction equation

HRID 93864 reaction equation
[Br:1][c:2]1[cH:3][n:4][c:5]([C:8](=[O:9])[NH:10][CH3:11])[n:6][cH:7]1.[CH2:12]([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[O:19][C:20]([CH:21]=[CH2:22])=[O:23].[CH2:46]([N:47]([CH2:48][CH2:49][CH2:50][CH3:51])[CH2:52][CH2:53][CH2:54][CH3:55])[CH2:56][CH2:57][CH3:58].[O-:65][C:66]([CH3:67])=[O:68].[O-:69][C:70]([CH3:71])=[O:72].[O:59]=[CH:60][N:61]([CH3:62])[CH3:63].[Pd+2:64].[c:24]1([CH3:25])[cH:26][cH:27][cH:28][cH:29][c:30]1[P:31]([c:32]1[cH:33][cH:34][cH:35][cH:36][c:37]1[CH3:38])[c:39]1[cH:40][cH:41][cH:42][cH:43][c:44]1[CH3:45]>>[c:2]1([CH:22]=[CH:21][C:20]([O:19][CH2:12][c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)=[O:23])[cH:3][n:4][c:5]([C:8](=[O:9])[NH:10][CH3:11])[n:6][cH:7]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 6228DimethylformamideHCID 7622TributylamineHCID 75617Benzyl acrylateHCID 80271Tri-o-tolylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 667599265-bromo-N-methylpyrimidine-2-carboxamide

Product 1

HCID 667593063-(2-Methylcarbamoyl-pyrimidin 5-yl)acrylic acid benzyl ester

Sources & evidence

ORD record
ord-275d6c093a4a4e9db807cf7a793396ed
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

Loading…