Hydrochloric Acid → N-{2-[4-(2-Bromo-5-methoxy-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-4-phenoxy-benzamide

HRID 955179

Reaction equation

HRID 955179 reaction equation
[Br:57][c:58]1[c:59]([C:60](=[O:61])[OH:62])[cH:63][c:64]([O:67][CH3:68])[cH:65][cH:66]1.[CH3:45][CH2:46][N:47]=[C:48]=[N:49][CH2:50][CH2:51][CH2:52][N:53]([CH3:54])[CH3:55].[CH:1]([N:2]([CH2:3][CH3:4])[CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9].[ClH:56].[O:10]=[C:11]([CH2:12][NH:13][C:14]([c:15]1[cH:16][cH:17][c:18]([O:21][c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[cH:19][cH:20]1)=[O:28])[N:29]1[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]1.[O:69]=[CH:70][N:71]([CH3:72])[CH3:73].[OH2:74].[OH:35][n:36]1[c:37]2[c:38]([cH:39][cH:40][cH:41][cH:42]2)[n:43][n:44]1>>[O:10]=[C:11]([CH2:12][NH:13][C:14]([c:15]1[cH:16][cH:17][c:18]([O:21][c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[cH:19][cH:20]1)=[O:28])[N:29]1[CH2:30][CH2:31][N:32]([C:60]([c:59]2[c:58]([Br:57])[cH:66][cH:65][c:64]([O:67][CH3:68])[cH:63]2)=[O:61])[CH2:33][CH2:34]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 962WaterHCID 6228DimethylformamideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 899062-Bromo-5-methoxybenzoic acidHCID 59559582N-(2-Oxo-2-piperazin-1-yl-ethyl)-4-phenoxy-benzamide

Product 1

HCID 25165722N-{2-[4-(2-Bromo-5-methoxy-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-4-phenoxy-benzamide

Sources & evidence

ORD record
ord-aeb0ee07dcd0484298075b78917bb8fd
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

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