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Hydrochloric Acid → HCID 20142835, compound

HRID 978061
Notes
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Reaction equation

HRID 978061 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[CH2:26]([O:28][C:29](=[O:32])[CH2:30][NH2:31])[CH3:27].Cl.N(CC)(CC)CC>C1COCC1>[CH2:26]([O:28][C:29](=[O:32])[CH2:30][NH:31][C:11](=[O:13])[CH2:10][CH2:9][CH2:8][CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH3:27]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 12176Glycine ethyl esterHCID 16757Benzenepentanoic acidHCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 20142835HCID 20142835, compound

Reagents, catalysts & solvents 1

On this pageParticipantsProcedureWorkupSources & evidenceReaction notes
HCID 8028
Tetrahydrofuran
Solvent

Procedure

5-Phenylvaleric acid (2.67 g, 15 mmol) in distilled THF was reacted with CDI (15 mmol) followed by glycine ethyl ester.HCl (15 mmol) and (C2H5)3N (15 mmol) as described in Example 56 Part A. The crude material (3.25 g, 82%) was used without purification.

Workup

  1. customThe crude material (3.25 g, 82%) was used without purification

Sources & evidence

ORD record
ord-5b4d167472444874aba9d700da25146b
Source dataset
uspto-grants-1987_05
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04663336

Reaction notes

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