Estradiol → Estradiol; Norethindrone Acetate

HRID 988926

Reaction equation

HRID 988926 reaction equation
[CH3:1][C@@:2]12[C@@H:18]([OH:19])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:20])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.[CH3:21][C:22]([O:24][C@:25]1([C:44]#[CH:45])[C@@:29]2([CH3:43])[CH2:30][CH2:31][C@@H:32]3[C@@H:42]4[C:36](=[CH:37][C:38]([CH2:40][CH2:41]4)=[O:39])[CH2:35][CH2:34][C@H:33]3[C@@H:28]2[CH2:27][CH2:26]1)=[O:23].CC(O)COC(CO)C.C(O)CCCCCCC/C=C\CCCCCCCC>C(O)(C)C.C1(C)C=CC=CC=1.C(OCC)(=O)C>[CH3:1][C@@:2]12[C@@H:18]([OH:19])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:20])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.[CH3:21][C:22]([O:24][C@:25]1([C:44]#[CH:45])[C@@:29]2([CH3:43])[CH2:30][CH2:31][C@@H:32]3[C@@H:42]4[C:36](=[CH:37][C:38]([CH2:40][CH2:41]4)=[O:39])[CH2:35][CH2:34][C@H:33]3[C@@H:28]2[CH2:27][CH2:26]1)=[O:23]

Participants

9

Reactant 5

HCID 5757EstradiolHCID 5832Norethisterone AcetateHCID 328812-(2-Hydroxypropoxy)-1-propanolHCID 5284499Oleyl AlcoholHCID 178527255HCID 178527255, compound

Product 1

HCID 3045253Estradiol; Norethindrone Acetate

Reagents, catalysts & solvents 3

HCID 1140TolueneSolventHCID 3776IsopropanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

An estradiol/norethindrone acetate pressure-sensitive adhesive matrix composition was prepared by combining 0.7 parts of estradiol and 3.0 parts of norethindrone acetate along with 3.0 parts of ethyl cellulose (Ethocele® 10, Dow Chemical Corp., Midland, Mich.) in 30.0 parts ethyl acetate, 15.0 parts of toluene and 10.0 parts isopropyl alcohol. Then 12.2 parts of a polyacrylate adhesive (DURO-TAIE® 87-2510; National Starch Company, Bridgewater, N.J.) and 109.2 parts of a polysiloxane adhesive (BIO-PSA® Q7-4603; Dow Corning Corp, Midland, Mich.) were added and thoroughly mixed. Finally 9.0 parts of dipropylene glycol and 6.0 parts oleyl alcohol were added and mixed thoroughly in an appropriate container until the mixture was completely homogenous. The resulting composition had the ingredient concentrations on a dry weight percent basis (i.e., after evaporation of volatile solvents) as shown below.

Workup

  1. additionthoroughly mixed
  2. additionmixed thoroughly in an appropriate container until the mixture
  3. concentrationthe ingredient concentrations
  4. customon a dry weight percent basis (i.e., after evaporation of volatile solvents)

Sources & evidence

ORD record
ord-19b297349b4b464a94791fb9bf448537
Source dataset
uspto-grants-2003_10
Patent number
US06638528B1

Linked notes

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