Sodium Hydroxide → 1-(4-Bromothiophen-2-yl)-N-methylmethanamine
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=O)[S:5][CH:6]=1.Cl.CN.[C:12]([BH3-])#[N:13].[Na+].[OH-].[Na+]>C(#N)C>[Br:1][C:2]1[CH:3]=[C:4]([CH2:7][NH:13][CH3:12])[S:5][CH:6]=1参加物
6
実験手順
10.6 g of 4-bromothiophene-2-carbaldehyde are dissolved in 100 mL of acetonitrile, and 11.8 g of methylamine hydrochloride and 6.28 g of sodium cyanoborohydride are added. The reaction mixture is stirred overnight at room temperature. The reaction is stopped with 1 M sodium hydroxide solution. After evaporating off the solvents, the residue is chromatographed on silica gel (7/3 heptane/ethyl acetate). 8.19 g of (4-bromothiophen-2-ylmethyl)methylamine are obtained. Yield=79%.
後処理
- customAfter evaporating off the solvents
- customthe residue is chromatographed on silica gel (7/3 heptane/ethyl acetate)
出典と根拠
- ORDレコード
- ord-02c4de786aed4f4b9f1579f5f6c8fcd7
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08129416B2
反応ノート
読み込み中…