Ammonia → 2-(1-methyl-1H-indol-3-yl)ethan-1-ol

HRID 127267

反応式

HRID 127267 の反応式
[NH2-].[Na+].[Na].N.[OH:5][CH2:6][CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1.[CH3:17]I>C(OCC)C>[CH3:17][N:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([CH2:7][CH2:6][OH:5])=[CH:9]1

参加物

7

反応物 5

HCID 222Ammonia2 回HCID 6328Methyl iodideHCID 10685TryptopholHCID 24533Sodium amideHCID 5360545Sodium

生成物 1

HCID 122478062-(1-methyl-1H-indol-3-yl)ethan-1-ol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a solution of sodium amide from 0.63 g sodium in 50 ml liquid ammonia is added in dropwise fashion a solution of 3.22 g of 3-(2-hydroxyethyl)indole in 10 ml diethyl ether. After stirring 10 minutes a solution of 1.37 ml methyl iodide in 1.5 ml diethyl ether is added in one portion. The mixture is stirred for 15 minutes and then the ammonia is allowed to evaporate. The residue is mixed with 100 ml water and is extracted into 200 ml diethyl ether. The organic phase is separated and is dried over magnesium sulfate. Filtration and evaporation affords 3.64 g of 1-methyl-3-(2-hydroxyethyl)indole, an oil.

後処理

  1. additionis added in one portion
  2. customto evaporate
  3. additionThe residue is mixed with 100 ml water
  4. extractionis extracted into 200 ml diethyl ether
  5. customThe organic phase is separated
  6. dry with materialis dried over magnesium sulfate
  7. filtrationFiltration and evaporation

出典と根拠

ORDレコード
ord-d961c34e52ac4a0fbaf51ea4925b98b8
出典データセット
uspto-grants-1981_03
特許番号
US04255432

関連ノート

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