Dimethyl Sulfoxide → HCID 18507323、化合物

反応式

C(O[C:4]([C:6]1[O:10][N:9]=[CH:8][CH:7]=1)=O)C.[CH2:11]([Li])[CH2:12][CH2:13]C.[H-].[Na+].CI.[N+:20]([O-])(O)=O.[NH2:24][C:25]([NH2:27])=[NH:26].C[S:29]([CH3:31])=O>C1COCC1.CN(C=O)C.C(N(CC)CC)C.C(=S)=S.C(#N)C>[NH2:26][C:25]1[N:27]=[C:4]([C:6]2[O:10][N:9]=[CH:8][CH:7]=2)[C:12]([C:13]#[N:20])=[C:11]([S:29][CH3:31])[N:24]=1

参加物

反応物 6

HCID 679Dimethyl Sulfoxide

HCID 6328Methyl iodide

HCID 10481Guanidine Nitrate

HCID 24758Sodium hydride

HCID 10701915Ethyl 1,2-oxazole-5-carboxylate

HCID 178418339Butyllithium

生成物 1

HCID 18507323HCID 18507323、化合物

試薬・触媒・溶媒 5

実験手順

From isoxazole-5-carboxylic acid ethyl ester with acetonitrile and butyllithium in THF. Then treatment with sodium hydride, carbon disulphide and methyl iodide in DMSO. Then treatment with guanidine nitrate and triethylamine in DMF. EI-MS m/e (%): 233 (M+, 45), 206 ([M—HCN]+, 100), 151 (33).