Hydrochloric Acid → N-Methacryloylalanine
反応式
[OH-].[Na+].[NH2:3][C@H:4]([C:6]([OH:8])=[O:7])[CH3:5].[C:9](Cl)(=[O:13])[C:10]([CH3:12])=[CH2:11].Cl>O.C1COCC1>[C:9]([NH:3][C@H:4]([C:6]([OH:8])=[O:7])[CH3:5])(=[O:13])[C:10]([CH3:12])=[CH2:11]参加物
7
実験手順
Sodium hydroxide (1.24 g) and L-alanine (2.76 g) were dissolved in pure water and, under cooling with ice, a solution where methacryloyl chloride (3 ml) was dissolved in THF (15 ml) and an aqueous solution (17 ml) containing sodium hydroxide (1.21 g) were simultaneously dropped thereinto. After that, the mixture was stirred at room temperature for 4 hours, acidified with 2M hydrochloric acid and extracted with ethyl acetate. The organic phase was dried, concentrated in vacuo, washed with ether and dried in vacuo to give the aimed product. Yield: 1.76 g (36%).
後処理
- temperatureunder cooling with ice
- additionwere simultaneously dropped
- extractionextracted with ethyl acetate
- customThe organic phase was dried
- concentrationconcentrated in vacuo
- washwashed with ether
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-2ff58a24337d409699399e706205e5d1
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07892834B2
反応ノート
読み込み中…