反応式
[Cl:1][C:2]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:5]2[O:6][CH:7]([CH2:9][NH2:10])[CH2:8][C:4]=2[CH:3]=1.C(N(C(C)C)CC)(C)C.Cl[C:27]([O:29][CH3:30])=[O:28].CC1C=CC(S(OC)(=O)=O)=CC=1>>[Cl:1][C:2]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:5]2[O:6][CH:7]([CH2:9][NH:10][C:27](=[O:28])[O:29][CH3:30])[CH2:8][C:4]=2[CH:3]=1参加物
5
実験手順
Treatment of (±)-(5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylamine (2.60 g, 9.62 mmol) with diisopropylethylamine (3.73 g, 28.85 mmol) and methyl chloroformate (1.36 g, 9.62 mmol) generally according to the procedure described for Intermediate 7 afforded 2.60 g (93%) of (±)-methyl (5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylcarbamate as a white solid. mp 128-130° C.; Anal. calcd. for C15H14ClNO3: C, 61.76; H, 4.84; N, 4.80. Found: C, 61.43; H, 4.87; N, 4.68.
出典と根拠
- ORDレコード
- ord-89a55ca56b2f4c6cad993fd79d796618
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07728155B2
関連ノート
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